Arden Key's thigh injury could sideline the Titans’ top edge in Week 5 against the Cardinals, forcing Tennessee to navigate without a heavy pass-rush contributor. If he misses time, Jeffery Simmons must anchor even more, and the Titans’ edge depth will be tested as Kyler Murray eyes time in the pocket.

Key’s value to Tennessee’s defense has been highlighted by pundits like PFF’s Jonathon Macri, who calls him underrated and notes a 77.2 pass-rush grade since 2021. Tennessee flashed in the second half vs Arizona, but the offense lagged, leaving Cam Ward to spark late drives and the defense to hold the line in a race to its first win without Key.

Titans aim to rebound in Week 5 against the Arizona Cardinals, led by Cam Ward’s steady, unflinching leadership after a rough 26-0 loss. Arizona’s run game is in flux with James Conner out and Trey Benson on IR, pushing the Cardinals toward a pass-first game plan Tennessee can capitalize on. Arizona’s porous interior line—six sacks allowed last week—opens a favorable path for Jeffery Simmons and Tennessee’s pass rush. This setup creates a meaningful fantasy window for Ward and several Titans playmakers.

The Cardinals’ RB room shakeup and the Titans’ disruptive front create an opportunity for Tennessee to control the tempo early. If Ward and the receiving corps click, Tennessee’s fantasy guys could post usable numbers even in a game that emphasizes defense. Arizona’s offense faces a stern test behind a weakened line, while Tennessee’s defense aims to maintain pressure and stifle a depleted run game, amplifying the upside for key fantasy assets from both teams.